Skip to main content

Research Repository

Advanced Search

Expanded subpopulation of FoxP3+ T regulatory cells in renal cell carcinoma co-express Helios, indicating they could be derived from natural but not induced Tregs (2011)
Journal Article
Elkord, E., Sharma, S., Burt, D., & Hawkins, R. (2011). Expanded subpopulation of FoxP3+ T regulatory cells in renal cell carcinoma co-express Helios, indicating they could be derived from natural but not induced Tregs. Clinical Immunology, 140(3), 218-222. https://doi.org/10.1016/j.clim.2011.04.014

Conversion of conventional T cells into T regulatory cells (Tregs) has been proposed as a potential mechanism for Treg expansion in cancer. However, this evidence is supported by in vitro or mouse model studies with no data from in vivo or human stud... Read More about Expanded subpopulation of FoxP3+ T regulatory cells in renal cell carcinoma co-express Helios, indicating they could be derived from natural but not induced Tregs.

Intracellular mapping with SERS-encoded gold nanostars (2011)
Journal Article
Rodríguez-Lorenzo, L., Krpetic, Z., Barbosa, S., Alvarez-Puebla, R., Liz-Marzán, L., Prior, I., & Brust, M. (2011). Intracellular mapping with SERS-encoded gold nanostars. Integrative Biology, 3(9), 922-926. https://doi.org/10.1039/C1IB00029B

Here we report on the design, synthesis and application of small, highly bright, star-shaped SERS encoded single nanoparticles with the ability of providing an optical signal upon excitation with near infrared light. These particles are colloidally s... Read More about Intracellular mapping with SERS-encoded gold nanostars.

Acrylate-facilitated cellular uptake of gold nanoparticles (2011)
Journal Article
Krpetic, Z., Nativo, P., Prior, I., & Brust, M. (2011). Acrylate-facilitated cellular uptake of gold nanoparticles. Small, 7(14), 1982-1986. https://doi.org/10.1002/smll.201100462

Uptake of PEGylated gold nanoparticles by HeLa cells in the presence of acrylate is described. Nanoparticles that are usually not taken up readily cross the plasma membrane into the cytosol in the presence of acrylate. In addition, a method is descri... Read More about Acrylate-facilitated cellular uptake of gold nanoparticles.

Negotiation of intracellular membrane barriers by TAT-Modified gold nanoparticles (2011)
Journal Article
Krpeticc, Z., Saleemi, S., Prior, I., Sée, V., Qureshi, R., & Brust, M. (2011). Negotiation of intracellular membrane barriers by TAT-Modified gold nanoparticles. ACS nano, 5(6), 5195-5201. https://doi.org/10.1021/nn201369k

This paper contributes to the debate on how nanosized objects negotiate membrane barriers inside biological cells. The uptake of peptide-modified gold nanoparticles by HeLa cells has been quantified using atomic emission spectroscopy. The TAT peptide... Read More about Negotiation of intracellular membrane barriers by TAT-Modified gold nanoparticles.

Novel IFNγ ELISPOT assay for detection of functional carcinoembryonic antigen-specific chimeric antigen receptor-redirected T cells (2011)
Journal Article
Elkord, E., & Burt, D. (2011). Novel IFNγ ELISPOT assay for detection of functional carcinoembryonic antigen-specific chimeric antigen receptor-redirected T cells. Scandinavian Journal of Immunology, 74(4), 419-422. https://doi.org/10.1111/j.1365-3083.2011.02588.x

We here describe the development of a novel ELISPOT assay for the detection and enumeration of IFNγ-secreting functional chimeric antigen receptor (CAR)-redirected T cells against carcinoembryonic antigen (CEA). This method is valuable for clinical t... Read More about Novel IFNγ ELISPOT assay for detection of functional carcinoembryonic antigen-specific chimeric antigen receptor-redirected T cells.

Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells (2011)
Journal Article
Khan, S., Burt, D., Ralph, C., Hawkins, R., & Elkord, E. (2011). Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells. Clinical Immunology, 138(1), 85-96. https://doi.org/10.1016/j.clim.2010.09.011

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) blockade has shown antitumor activity against common cancers. However, the exact mechanism of immune mediation by anti-CTLA4 remains to be elucidated. Further understanding of how CTLA4 blockade with tremelimu... Read More about Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells.

Circulating regulatory T cells in endometrial cancer: a role for age and menopausal status (2011)
Journal Article
Sawan, S., Burt, D., Stern, P., Holland, C., & Elkord, E. (2011). Circulating regulatory T cells in endometrial cancer: a role for age and menopausal status. Immunological Investigations, 40(1), 62-75. https://doi.org/10.3109/08820139.2010.513022

Regulatory T cells (Treg) are a sub-population of T cells that suppress self-reactivity and are implicated in immune tolerance towards malignant cells. Circulating Treg cells are increased in several cancers. In endometrial cancer Treg cells have bee... Read More about Circulating regulatory T cells in endometrial cancer: a role for age and menopausal status.

Prevalence and co-infection of Toxoplasma gondii and Neospora caninum in Apodemus sylvaticus in an area relatively free of cats (2011)
Journal Article

The protozoan parasite Toxoplasma gondii is prevalent worldwide and can infect a remarkably wide range of hosts despite
felids being the only definitive host. As cats play a major role in transmission to secondary mammalian hosts, the interaction
b... Read More about Prevalence and co-infection of Toxoplasma gondii and Neospora caninum in Apodemus sylvaticus in an area relatively free of cats.

Cellular biochemical and experimental therapeutic studies of L-glutamine and L-asparagine depletion for paediatric sarcoma cells (2011)
Thesis
Allsup, J. Cellular biochemical and experimental therapeutic studies of L-glutamine and L-asparagine depletion for paediatric sarcoma cells. (Thesis). University of Salford

The aim of this project was to investigate the cellular biochemical and experimental therapeutic effects of L-glutamine (gin) and L-asparagine (asn) depletion for
paediatric sarcoma cells. The work presented in this thesis describes preclinical stud... Read More about Cellular biochemical and experimental therapeutic studies of L-glutamine and L-asparagine depletion for paediatric sarcoma cells.

The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa (2011)
Journal Article
Fothergill, J., Mowat, E., Walshaw, M., Ledson, M., James, C., & Winstanley, C. (2011). The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 55(1), 426-428. https://doi.org/10.1128/AAC.01257-10

Phage production in response to antibiotics varied among four isolates of a Pseudomonas aeruginosa
cystic fibrosis (CF) epidemic strain. Whereas ciprofloxacin induced higher levels of phage production,
other CF-relevant antibiotics led to reduced p... Read More about The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa.