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Complement C5a and clinical markers as predictors of COVID-19 disease severity and mortality in a multi-ethnic population (2021)
Journal Article

Coronavirus disease-2019 (COVID-19) was declared as a pandemic by WHO in March 2020. SARS-CoV-2 causes a wide range of illness from asymptomatic to life-threatening. There is an essential need to identify biomarkers to predict disease severity and mo... Read More about Complement C5a and clinical markers as predictors of COVID-19 disease severity and mortality in a multi-ethnic population.

Selected derivatives of erythromycin B- in silico and anti-malarial studies (2021)
Journal Article
Bhadra, P., Magwaza, R., Nirmalan, N., Freeman, S., Barber, J., & Arsic, B. (2021). Selected derivatives of erythromycin B- in silico and anti-malarial studies. Materials, 14(22), e6980. https://doi.org/10.3390/ma14226980

Erythromycin A is an established anti-bacterial agent against Gram-positive bacteria, but it is unstable to acid. This led to an evaluation of erythromycin B and its derivatives because these have improved acid stability. These compounds were investi... Read More about Selected derivatives of erythromycin B- in silico and anti-malarial studies.

High ATP production fuels cancer drug resistance and metastasis : implications for mitochondrial ATP depletion therapy (2021)
Journal Article
Fiorillo, M., Ozsvari, B., Sotgia, F., & Lisanti, M. (2021). High ATP production fuels cancer drug resistance and metastasis : implications for mitochondrial ATP depletion therapy. Frontiers in Oncology, 11, 740720. https://doi.org/10.3389/fonc.2021.740720

Recently, we presented evidence that high mitochondrial ATP production is a new therapeutic target for cancer treatment. Using ATP as a biomarker, we isolated the “metabolically fittest” cancer cells from the total cell population. Importantly, ATP-h... Read More about High ATP production fuels cancer drug resistance and metastasis : implications for mitochondrial ATP depletion therapy.

Investigation of de-novo copy number variants in patients with Autism Spectrum Disorder in Vietnam (2021)
Thesis
Bui, H. Investigation of de-novo copy number variants in patients with Autism Spectrum Disorder in Vietnam. (Thesis). University of Salford

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a prevalence of approximately 1% children worldwide. ASD is characterized by deficits in social communication and interaction and the presence of restricted interests and repetitive... Read More about Investigation of de-novo copy number variants in patients with Autism Spectrum Disorder in Vietnam.

SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line (2021)
Journal Article

Background: The human SH3 domain Binding Glutamic acid Rich Like 3 (SH3BGRL3) gene is highly conserved in phylogeny and widely expressed in human tissues. However, its function is largely undetermined. The protein was found to be overexpressed in sev... Read More about SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.

Characterization of sialic acid affinity of the binding domain of mistletoe lectin isoform one (2021)
Journal Article
Mohammed, S., & Ferry, N. (2021). Characterization of sialic acid affinity of the binding domain of mistletoe lectin isoform one. International Journal of Molecular Sciences, 22(15), e8284. https://doi.org/10.3390/ijms22158284

Sialic acid (Sia) is considered as one of the most important biomolecules of life since its derivatives and terminal orientations on cell membranes and macromolecules play a major role in many biological and pathological processes. To date, there is... Read More about Characterization of sialic acid affinity of the binding domain of mistletoe lectin isoform one.

Integrated whole transcriptome and small RNA analysis revealed multiple regulatory networks in colorectal cancer (2021)
Journal Article
Shaath, H., Toor, S., Nada, M., Elkord, E., & Alajez, N. (2021). Integrated whole transcriptome and small RNA analysis revealed multiple regulatory networks in colorectal cancer. Scientific reports, 11(1), 14456. https://doi.org/10.1038/s41598-021-93531-y

Colorectal cancer (CRC) remains a global disease burden and a leading cause of cancer related deaths worldwide. The identification of aberrantly expressed messenger RNA (mRNA), long non-coding RNA (lncRNA), and microRNA (miRNA), and the resulting mol... Read More about Integrated whole transcriptome and small RNA analysis revealed multiple regulatory networks in colorectal cancer.

The chemotherapeutic potential of Boswellia carterii oleoresins (2021)
Thesis
Jones, M. The chemotherapeutic potential of Boswellia carterii oleoresins. (Thesis). University of Salford

Cancer is a leading cause of death worldwide. Though effective treatments are available and reduce mortality, issues such as debilitating side-effects and drug resistance necessitate a need to develop alternatives. Natural products are a key and dive... Read More about The chemotherapeutic potential of Boswellia carterii oleoresins.

Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma (2021)
Thesis
Hoyles, N. Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma. (Dissertation). University of Salford

Understanding the function of the HGF-Met signalling axis could present opportunities for new therapeutic treatments for cancer patients. The brain tumour Medulloblastoma is the leading cause of cancer-related death in children and infants meaning re... Read More about Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma.

Exploring the influence of adipokines on neuronal function in Alzheimer’s disease (2021)
Thesis
Tomar, N. Exploring the influence of adipokines on neuronal function in Alzheimer’s disease. (Thesis). University of Salford

Alzheimer’s disease (AD) is one of the major causes of dementia. Alzheimer’s disease is an irreversible, slow neurodegenerative disease leading to memory and language impairment and amyloid-β plaques and intraneuronal neurofibrillary tangles are the... Read More about Exploring the influence of adipokines on neuronal function in Alzheimer’s disease.

Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents (2021)
Thesis
Ahmed, S. M. Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents. (Thesis). University of Salford

Seen as one of the major causes of death worldwide, Cancer requires the development of effective treatments to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound that can ove... Read More about Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents.

In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation (2021)
Journal Article

Advances in nanofabrication methods have enabled the tailoring of new strategies towards the controlled production of nanoparticles with attractive applications in healthcare. In many cases, their characterisation remains a big challenge, particularl... Read More about In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation.

Restoring perivascular adipose tissue function in obesity using exercise (2021)
Journal Article
Saxton, S., Toms, L., Aldous, R., Withers, S., Ohanian, J., & Heagerty, A. (2021). Restoring perivascular adipose tissue function in obesity using exercise. Cardiovascular Drugs and Therapy, 35(6), 1291-1304. https://doi.org/10.1007/s10557-020-07136-0

Perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating vascular tone. This effect is mediated via sympathetic nervous stimulation of PVAT by a mechanism which involves noradrenaline uptake through organic ca... Read More about Restoring perivascular adipose tissue function in obesity using exercise.

An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue (2021)
Thesis
Soothill, H. An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue. (Dissertation). University of Salford

This study aimed to investigate the relationship between Toxoplasma gondii infection and the expression of the immune modulating proteins Arginase-1 and iNOS in human lung biopsy samples. Previously, a 100% toxoplasmosis infection rate was found in 7... Read More about An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue.

Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma (2021)
Thesis
Abbood, L. Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma. (Dissertation). University of Salford

Trauma is a leading cause of death and disability. Globally, traumatic injury is the main cause of death under the age of 45. Recent studies from the UK report a demographic change in major trauma. The most common mechanism of traumatic injury is fal... Read More about Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma.