Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases (2003)
Journal Article
Karahalil, B., de Souza-Pinto, N., Parsons, J., Elder, R., & Bohr, V. (2003). Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases. Journal of Biological Chemistry, 278(36), 33701-7. https://doi.org/10.1074/jbc.M301617200

Mitochondrial DNA is constantly exposed to high levels of endogenously produced reactive oxygen species, resulting in elevated levels of oxidative damaged DNA bases. A large spectrum of DNA base alterations can be detected after oxidative stress, and... Read More about Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases.

Measurement of 4-hydroxy-2,2,6,6-tetramethyl-piperidine-N-oxyl by high performance liquid chromatography-electrospray ionisation mass spectrometry (2002)
Journal Article
Podmore, I. (2002). Measurement of 4-hydroxy-2,2,6,6-tetramethyl-piperidine-N-oxyl by high performance liquid chromatography-electrospray ionisation mass spectrometry. Journal of Chemical Research, 574-575. https://doi.org/10.3184/030823402103170835

Reverse phase high performance liquid chromatography coupled to electrospray ionisation mass spectrometry and tandem mass spectrometry has allowed quantitative measurement of a stable nitroxide, 4-hydroxy-2,2,6,6-tetramethyl-piperidine-N-oxyl (4-hydr... Read More about Measurement of 4-hydroxy-2,2,6,6-tetramethyl-piperidine-N-oxyl by high performance liquid chromatography-electrospray ionisation mass spectrometry.

Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies (2002)
Journal Article

Background: Vascular endothelial growth factor (VEGF) is a
potent angiogenic cytokine, and various inhibitory agents,
including specific antibodies, have been developed to block
VEGF-stimulated angiogenesis. We developed HuMV833,
a humanized vers... Read More about Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies.

Rapid dot-ELISA for the detection of specific antigens in the cyst fluid from human cases of cystic echinococcosis. (2002)
Journal Article
Wang, Y., Bradshaw, H., Rogan, M., & Craig, P. (2002). Rapid dot-ELISA for the detection of specific antigens in the cyst fluid from human cases of cystic echinococcosis. Annals of Tropical Medicine and Parasitology, 96(7), 691-694. https://doi.org/10.1179/000349802125001717

A rapid dot-ELISA was developed for the detection of specific antigens in samples of cyst fluid from human cases of Echinococcus granulosus infection, permitting the confirmation of cystic echinococcosis (CE). Peroxidase-conjugated antibodies against... Read More about Rapid dot-ELISA for the detection of specific antigens in the cyst fluid from human cases of cystic echinococcosis..

Measurement of nanosecond time-resolved fluorescence with a directly gated interline CCD camera (2002)
Journal Article
Mitchell, A., Wall, J., Murray, J., & Morgan, C. (2002). Measurement of nanosecond time-resolved fluorescence with a directly gated interline CCD camera. Journal of Microscopy, 206(3), 233-238. https://doi.org/10.1046/j.1365-2818.2002.01030.x

CCD cameras coupled optically to gated image intensifiers have been used for fast time-resolved measurements for some years. Image intensifiers have disadvantages, however, and for some applications it would be better if the image sensor could be gat... Read More about Measurement of nanosecond time-resolved fluorescence with a directly gated interline CCD camera.

Direct modulation of the effective sensitivity of a CCD detector: a new approach to time-resolved fluorescence imaging (2002)
Journal Article
Mitchell, A., Wall, J., Murray, J., & Morgan, C. (2002). Direct modulation of the effective sensitivity of a CCD detector: a new approach to time-resolved fluorescence imaging. Journal of Microscopy, 206(3), 225-232. https://doi.org/10.1046/j.1365-2818.2002.01029.x

In this paper a novel approach to frequency-domain fluorescence lifetime imaging (FLIM) is described. In a CCD camera a single pixel is defined by a charge pattern on a group of electrodes. By modulation of the pattern of voltages defining the pixel... Read More about Direct modulation of the effective sensitivity of a CCD detector: a new approach to time-resolved fluorescence imaging.

Monte Carlo simulations of polyion−macroion complexes. 1. Equal absolute polyion and macroion charges (2002)
Journal Article
Akinshina, A., & Linse, P. (2002). Monte Carlo simulations of polyion−macroion complexes. 1. Equal absolute polyion and macroion charges. Macromolecules, 35(13), 5183-5193. https://doi.org/10.1021/ma012052u

Intermolecular structures of complexes formed between a charged polymer and a spherical
and oppositely charged macroion have been studied by employing the primitive model solved by Monte
Carlo simulations. The strong-complex case involving a polyio... Read More about Monte Carlo simulations of polyion−macroion complexes. 1. Equal absolute polyion and macroion charges.

Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts (2002)
Journal Article
Elder, R., & Dianov, G. (2002). Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts. Journal of Biological Chemistry, 277(52), 50487-90. https://doi.org/10.1074/jbc.M208153200

In mammalian cells, thymine glycols and other oxidized pyrimidines such as 5,6-dihydrouracil are removed from DNA by the NTH1 protein, a bifunctional DNA-N-glycosylase. However, mNTH1 knock-out mice in common with other DNA glycosylase-deficient mice... Read More about Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts.

The stage-regulated expression of leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element (2001)
Journal Article
Brooks, D., Denise, H., Westrop, G., Coombs, G., & Mottram, J. (2001). The stage-regulated expression of leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element. Journal of Biological Chemistry, 276(50), 47061-47069. https://doi.org/10.1074/jbc.M108498200

The tandemly-arranged CPB genes of Leishmania mexicana are polycistronically transcribed and encode cysteine proteases that are differentially stage-specific; CPB1 and CPB2 being expressed predominantly in metacyclics whereas CPB3-CPB18 are expressed... Read More about The stage-regulated expression of leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element.

Novel syntheses of cis and trans isomers of combretastatin A-4 (2001)
Journal Article
Gaukroger, K., Hadfield, J., Hepworth, L., Lawrence, N., & McGown, A. (2001). Novel syntheses of cis and trans isomers of combretastatin A-4. Journal of Organic Chemistry, 66(24), 8135-8138. https://doi.org/10.1021/jo015959z

A high-yielding, two-step stereoselective synthesis of the anticancer drug (Z)-combretastatin A-4 (1) has been devised. The method uses the Perkin condensation of 3,4,5-trimethoxyphenylacetic acid and 3-hydroxy-4-methoxybenzaldehyde followed by decar... Read More about Novel syntheses of cis and trans isomers of combretastatin A-4.

Linked parallel synthesis and MTT bioassay screening of substituted chalcones (2001)
Journal Article
Lawrence, N., Rennison, D., McGown, A., Ducki, S., Gul, L., Hadfield, J., & Khan, N. (2001). Linked parallel synthesis and MTT bioassay screening of substituted chalcones. Journal of Combinatorial Chemistry, 3(5), 421-426. https://doi.org/10.1021/cc000075z

A 644-membered library of chalcones was prepared by parallel synthesis using the Claisen-Schmidt base-catalyzed aldol condensation of substituted acetophenones and benzaldehydes. The cytotoxicity of these chalcones was conveniently determined upon th... Read More about Linked parallel synthesis and MTT bioassay screening of substituted chalcones.

In-vitro susceptibility of hydatid cysts of echinococcus granulosus to nitric oxide and the effect of the laminated layer on nitric oxide production (2001)
Journal Article
Steers, N., Rogan, M., & Heath, S. (2001). In-vitro susceptibility of hydatid cysts of echinococcus granulosus to nitric oxide and the effect of the laminated layer on nitric oxide production. Parasite Immunology, 23(8), 411-417. https://doi.org/10.1046/j.1365-3024.2001.00385.x

Murine hydatid cysts of Echinococcus granulosus were incubated in vitro in the presence of nitric oxide produced from S-nitroso-N-acetylpenicillamine (SNAP) or interferon-gamma activated peritoneal macrophages. In both situations, evidence of cyst da... Read More about In-vitro susceptibility of hydatid cysts of echinococcus granulosus to nitric oxide and the effect of the laminated layer on nitric oxide production.

Spinal cord injury in Saudi Arabia : characteristics, bone mineral density, and functional electrical stimulation for upright mobility (1999)
Thesis
AboAbat, A. Spinal cord injury in Saudi Arabia : characteristics, bone mineral density, and functional electrical stimulation for upright mobility. (Thesis). Salford : University of Salford

A nation-wide SCI survey was conducted for the first time in Saudi Arabia. It showed that the current situation and characteristic features of SCI patients was significantly different from that in other countries and there is deficiency in medical an... Read More about Spinal cord injury in Saudi Arabia : characteristics, bone mineral density, and functional electrical stimulation for upright mobility.

The effects of training and substrate manipulation upon the metabolic and hormonal responses to graded exercise (1984)
Thesis
Jakeman, P. The effects of training and substrate manipulation upon the metabolic and hormonal responses to graded exercise. (Thesis). Salford : University of Salford

The purpose of this study was to investigate the effects of training
and substrate manipulation upon the physiological and metabolic response to
graded exercise for both trained and non-trained subjects. A major interest
of this work was the conce... Read More about The effects of training and substrate manipulation upon the metabolic and hormonal responses to graded exercise.

Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells
Thesis
Jones, C. Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells. (Thesis). University of Salford

Introduction: Leukaemia is cancer of white blood cells (WBCs) mainly affecting children. Defective WBCs are prominent in blood and cannot provide immune protection. Although chemotherapy treatments are effective, they have many adverse effects which... Read More about Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells.

Effect of omega-3 polyunsaturated fatty acids on inflammatory biomarkers in chronic obstructive pulmonary disease
Thesis
Al-Haidose, A. Effect of omega-3 polyunsaturated fatty acids on inflammatory biomarkers in chronic obstructive pulmonary disease. (Thesis). University of Salford

Chronic obstructive pulmonary disease (COPD) is a chronic progressive inflammatory disease characterised by airflow limitation. Several pro-inflammatory markers are thought to be involved in the pathogenesis of COPD. Cigarette smoking is a major risk... Read More about Effect of omega-3 polyunsaturated fatty acids on inflammatory biomarkers in chronic obstructive pulmonary disease.

The PAM-1 aminopeptidase regulates microtubule dynamics during meiosis and polarity establishment in the early C. elegans embryo
Presentation / Conference
Greene, P., Marshall, S., Brady, L., Reeves, C., Brooks, D., Isaac, E., & Lyczak, R. The PAM-1 aminopeptidase regulates microtubule dynamics during meiosis and polarity establishment in the early C. elegans embryo. Poster presented at 17th International C. elegans Meeting, UCLA, Los Angeles

Isolation of novel antibiotic producing microorganisms from invertebrates
Thesis
Ghanbour, H. (in press). Isolation of novel antibiotic producing microorganisms from invertebrates. (Thesis). University of Salford

Because of the increased incidence of antibiotic resistance there is an increasing need to isolate new microorganisms producing new antibiotics. Because conventional sources such as soil have been exhausted, attention has been turned to unexplored so... Read More about Isolation of novel antibiotic producing microorganisms from invertebrates.

Investigating calcium channel blockers as antimalarials
Thesis
Rajab, M. (in press). Investigating calcium channel blockers as antimalarials. (Thesis). University of Salford

The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioning screens carried out at the University of Salford ident... Read More about Investigating calcium channel blockers as antimalarials.

Dental biofilm formation in young children and the long term effects of fluoride varnish
Thesis
Greenwood, D. Dental biofilm formation in young children and the long term effects of fluoride varnish. (Thesis). University of Salford

Introduction: Fluoride is widely used as a method of reducing caries and while much is known about the processes involved in enamel remineralisation the effects of fluoride on indigenous biofilms in vivo are unclear. Aims: The aim of this study was t... Read More about Dental biofilm formation in young children and the long term effects of fluoride varnish.