Dissecting tumor metabolic heterogeneity : Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells (2015)
Journal Article

Tumor cell metabolic heterogeneity is thought to contribute to tumor recurrence, distant metastasis and chemo-resistance in cancer patients, driving poor clinical outcome. To better understand tumor metabolic heterogeneity, here we used the MCF7 brea... Read More about Dissecting tumor metabolic heterogeneity : Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells.

Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose (2015)
Journal Article
Peiris-Pagès, M., Sotgia, F., & Lisanti, M. (2015). Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose. Oncoscience, 2(8), 696-699. https://doi.org/10.18632/oncoscience.215

There is a small proportion of cells within a tumour with self-renewing properties, which is resistant to conventional therapy, and is responsible for tumour initiation, maintenance and metastasis. These cells are known as cancer stem cells (CSCs) or... Read More about Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose.

Transmission of Echinococcus species in pastoral communities in southern Kyrgyzstan (2015)
Presentation / Conference Contribution

Echinococcus granulosus and human cystic echinococcosis (CE) are highly endemic in Central Asia and western China. Human alveolar echinococcosis (AE) is an emergent public health problem in Kyrgyzstan and in the Region. Community, veterinary and ecol... Read More about Transmission of Echinococcus species in pastoral communities in southern Kyrgyzstan.

Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC) (2015)
Journal Article

The pathogenesis of the adrenocortical cancer (ACC) involves integration of molecular signals and the interplay of different downstream pathways (i.e. IGFII/IGF1R, β-catenin, Wnt, ESR1). This tumor is characterized by limited therapeutic options and... Read More about Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC).

Altered expression and editing of miRNA-100 regulates iTreg differentiation (2015)
Journal Article

RNA editing ofmiRNAs, especially in the seed region,
adds another layer to miRNA mediated gene regulation
which can modify its targets, altering cellular signaling
involved in important processes such as differentiation.
In this study, we have ex... Read More about Altered expression and editing of miRNA-100 regulates iTreg differentiation.

MYC is a major determinant of mitotic cell fate (2015)
Journal Article

Taxol and other antimitotic agents are frontline chemotherapy agents but the mechanisms responsible for patient benefit remain unclear. Following a genome-wide siRNA screen, we identified the oncogenic transcription factor Myc as a taxol sensitizer.... Read More about MYC is a major determinant of mitotic cell fate.

Cytotoxicity and genotoxicity of urban particulate matter in mammalian cells (2015)
Journal Article
Dumax-Vorzet, A., Tate, M., Walmsley, R., Elder, R., & Povey, A. (2015). Cytotoxicity and genotoxicity of urban particulate matter in mammalian cells. Mutagenesis, 30(5), 621-633. https://doi.org/10.1093/mutage/gev025

Ambient air particulate matter (PM)-associated reactive oxygen species (ROS) have been linked to a variety of altered cellular outcomes. In this study, three different PM samples from diesel exhaust particles (DEPs), urban dust standard reference mat... Read More about Cytotoxicity and genotoxicity of urban particulate matter in mammalian cells.

Human enhancement in sports (2015)
Book Chapter
Miah, A. (2015). Human enhancement in sports. In W. Bainbridge, & M. Roco (Eds.), Handbook of Science and Technology Convergence (1-13). Springer. https://doi.org/10.1007/978-3-319-04033-2_85-1

This chapter examines the range of sciences and technologies that converge around sports and the implications of this for issues of fairness and ethics. First, it outlines some of the recent scientific developments that speak to the convergence of di... Read More about Human enhancement in sports.

Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1 (2015)
Presentation / Conference
Al-Sudani, B., Krstic- Demonacos, M., & Ragazzon, P. (2015, June). Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1. Poster presented at EuroMedLab Paris 2015, Paris, France

The word ‘sirtuin’ (SIR) stands for Silent Information Regulator. SIRT1 is the most studied mammalian sirtuin and predominantly localises to the nucleus. Many sirtuins targets are involved in cancer and in many types of cancers, SIRT1 is found to be... Read More about Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1.

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells (2015)
Journal Article

Here, we show that new mitochondrial biogenesis is required for the anchorage independent survival and propagation of cancer stem-like cells (CSCs). More specifically, we used the drug XCT790 as an investigational tool, as it functions as a specific... Read More about Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells.

The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca(2+) handling in rat ventricular myocytes (2015)
Journal Article
Miller, L., Greensmith, D., Sankaranarayanan, R., O'Neill, S., & Eisner, D. (2015). The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca(2+) handling in rat ventricular myocytes. Cell Calcium, 58(2), 208-14. https://doi.org/10.1016/j.ceca.2015.05.002

2,5-Di-(tert-butyl)-1,4-benzohydroquinone (TBQ) is a reversible inhibitor of SERCA, potentially making it a useful tool to study the effects of SERCA inhibition in cardiac cells. However, it is unknown if TBQ also has effects on other components of v... Read More about The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca(2+) handling in rat ventricular myocytes.

Asymmetric synthesis of diarylmethane derivatives by dynamic kinetic resolution (2015)
Journal Article
kinetic resolution. Tetrahedron Letters, 56(26), 4025-4027. https://doi.org/10.1016/j.tetlet.2015.05.006

Asymmetric allylation of ortho-methoxydiphenylmethane has been carried out with high yields and ee of up to 94% using the chiral ligand (−)-sparteine as an additive. Results of reactions performed under various conditions suggest that a dynamic kinet... Read More about Asymmetric synthesis of diarylmethane derivatives by dynamic kinetic resolution.

Caveolae and signalling in cancer (2015)
Journal Article
Martinez-Outschoorn, U., Sotgia, F., & Lisanti, M. (2015). Caveolae and signalling in cancer. Nature Reviews Cancer, 15(4), 225-37. https://doi.org/10.1038/nrc3915

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most extensively studied subset of lipid rafts. A newly emerging paradig... Read More about Caveolae and signalling in cancer.

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease (2015)
Journal Article

Here, we propose a new strategy for the treatment of early cancerous lesions and advanced metastatic disease, via the selective targeting of cancer stem cells (CSCs), a.k.a., tumor-initiating cells (TICs). We searched for a global phenotypic characte... Read More about Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease.

Reversible redox modulation of a lanthanide emissive molecular film (2015)
Journal Article
Lehr, J., Tropiano, M., Beer, P., Faulkner, S., & Davis, J. (2015). Reversible redox modulation of a lanthanide emissive molecular film. Chemical Communications, 51(30), 6515-6517. https://doi.org/10.1039/c5cc01097g

Herein we demonstrate redox switchable emission from a sensitised, europium–ferrocene containing, molecular film assembled by a novel nitrene-based strategy. Electrochemical modulation of europium emission upon switching the ferrocene moiety's redox... Read More about Reversible redox modulation of a lanthanide emissive molecular film.

Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile (2015)
Journal Article
Kuroda, K., Fukuda, T., Isogai, H., Okumura K, K., Krstic-Demonacos, M., & Isogai, E. (2015). Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile. International Journal of Oncology, 46(4), 1516-1526. https://doi.org/10.3892/ijo.2015.2887

Metabolic reprogramming is one of the hallmarks of cancer and can be targeted by therapeutic agents. We previously reported that cathelicidin-related or modified antimicrobial peptides, such as FF/CAP18, have antiproliferative effects on the squamous... Read More about Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile.

A series of flexible design adaptations to the Nikon E-C1 and E-C2 confocal microscope systems for UV, multiphoton and FLIM imaging (2015)
Journal Article
Botchway, S., Scherer, K., Hook, S., Stubbs, C., Weston, E., Bisby, R., & Parker, A. (2015). A series of flexible design adaptations to the Nikon E-C1 and E-C2 confocal microscope systems for UV, multiphoton and FLIM imaging. Journal of Microscopy, 258(1), 68-78. https://doi.org/10.1111/jmi.12218

Multiphoton microscopy in combination with Fluorescence Lifetime Imaging Microscopy (FLIM) is now a key technique in biomedical and life-science research for live cell and whole animal imaging providing several advantages over the one photon confocal... Read More about A series of flexible design adaptations to the Nikon E-C1 and E-C2 confocal microscope systems for UV, multiphoton and FLIM imaging.

Independent evaluation of a canine Echinococcosis control programme in Hobukesar County, Xinjiang, China (2015)
Journal Article

The Xinjiang Uyghur Autonomous Region in northwest China is one of the world's most important foci for cystic echinococcosis. Domestic dogs are the main source for human infection, and previous studies in Xinjiang have found a canine Echinococcus spp... Read More about Independent evaluation of a canine Echinococcosis control programme in Hobukesar County, Xinjiang, China.

Development of novel heterocyclic compounds as vascular targeting agents (2015)
Thesis
Killoran, P. Development of novel heterocyclic compounds as vascular targeting agents. (Thesis)

In chapter one the biology of cancer is introduced along with a brief history of drug treatment and the status quo of cancer therapeutics. This includes a general overview of cancer prevalence, carcinogenesis, and biochemistry. The main targets for c... Read More about Development of novel heterocyclic compounds as vascular targeting agents.

Current challenges in volatile organic compounds analysis as potential biomarkers of cancer (2015)
Journal Article
Schmidt, K., & Podmore, I. (2015). Current challenges in volatile organic compounds analysis as potential biomarkers of cancer. Journal of Biomarkers (Online), 2015(981458), https://doi.org/10.1155/2015/981458

An early diagnosis and appropriate treatment are crucial in reducing mortality among people suffering from cancer. There is a lack of characteristic early clinical symptoms in most forms of cancer, which highlights the importance of investigating new... Read More about Current challenges in volatile organic compounds analysis as potential biomarkers of cancer.