Development of novel heterocyclic compounds as vascular targeting agents (2015)
Thesis
Killoran, P. Development of novel heterocyclic compounds as vascular targeting agents. (Thesis)

In chapter one the biology of cancer is introduced along with a brief history of drug treatment and the status quo of cancer therapeutics. This includes a general overview of cancer prevalence, carcinogenesis, and biochemistry. The main targets for c... Read More about Development of novel heterocyclic compounds as vascular targeting agents.

Current challenges in volatile organic compounds analysis as potential biomarkers of cancer (2015)
Journal Article
Schmidt, K., & Podmore, I. (2015). Current challenges in volatile organic compounds analysis as potential biomarkers of cancer. Journal of Biomarkers (Online), 2015(981458), https://doi.org/10.1155/2015/981458

An early diagnosis and appropriate treatment are crucial in reducing mortality among people suffering from cancer. There is a lack of characteristic early clinical symptoms in most forms of cancer, which highlights the importance of investigating new... Read More about Current challenges in volatile organic compounds analysis as potential biomarkers of cancer.

Post-encystment/established immunity in cystic echinococcosis : is it really that simple? (2015)
Journal Article
Rogan, M., Bodell, A., & Craig, P. (2015). Post-encystment/established immunity in cystic echinococcosis : is it really that simple?. Parasite Immunology, 37(1), 1-9. https://doi.org/10.1111/pim.12149

In 1982, Rickard & Williams stated that immunity to larval taeniid cestodes could be divided into two different phases: the establishment phase, operating against oncospheres, and the established phase, operating against established metacestodes in t... Read More about Post-encystment/established immunity in cystic echinococcosis : is it really that simple?.

Graphene oxide interfaces in serum based autoantibody quantification (2014)
Journal Article
Xu, Q., Cheng, H., Lehr, J., Patil, A., & Davis, J. (2015). Graphene oxide interfaces in serum based autoantibody quantification. Analytical Chemistry, 87(1), 346-350. https://doi.org/10.1021/ac503890e

A reliable quantification of protein markers will undoubtedly underpin profound developments in disease surveillance, diagnostics, and improved therapy. Although there potentially exist numerous means of achieving this, electrochemical impedimetric t... Read More about Graphene oxide interfaces in serum based autoantibody quantification.

Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering (2014)
Journal Article
Masetti, M., Xie, H., Krpetic, Z., Recanatini, M., Alvarez-Puebla, R., & Guerrini, L. (2015). Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering. Abstracts of papers / American Chemical Society, 137(1), 469-476. https://doi.org/10.1021/ja511398w

The standard protocols for DNA analysis largely involve polymerase chain reaction (PCR). However, DNA structures bound to chemical agents cannot be PCR-amplified, and therefore any sequence changes induced by external agents may be neglected. Thus, t... Read More about Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering.

Antimicrobial susceptibility patterns of Methicillin-resistant staphylococcus aureus isolates collected from healthcare and community facilities in Libya show a high level of resistance to fusidic acid (2014)
Journal Article
Warag, S., Foster, H., & Daw, M. (2014). Antimicrobial susceptibility patterns of Methicillin-resistant staphylococcus aureus isolates collected from healthcare and community facilities in Libya show a high level of resistance to fusidic acid. Journal of infectious disease and therapy, 2(189), https://doi.org/10.4172/2332-0877.1000189

Staphylococcus aureus is an important human pathogen and is implicated in a wide variety of infections in the healthcare and community settings. The organism is often subcategorized as community-associated MRSA (CA-MRSA) or health care-associated MRS... Read More about Antimicrobial susceptibility patterns of Methicillin-resistant staphylococcus aureus isolates collected from healthcare and community facilities in Libya show a high level of resistance to fusidic acid.

Thermodynamics of the self-assembly of non-ionic chromonic molecules using atomistic simulations. The case of TP6EO2M in aqueous solution (2014)
Journal Article
The case of TP6EO2M in aqueous solution. Soft Matter, 11(4), 680-691. https://doi.org/10.1039/c4sm02275k

Atomistic molecular dynamic simulations have been performed for the non-ionic chromonic liquid crystal 2,3,6,7,10,11-hexa-(1,4,7-trioxa-octyl)-triphenylene (TP6EO2M) in aqueous solution. TP6EO2M molecules consist of a central poly-aromatic core (a tr... Read More about Thermodynamics of the self-assembly of non-ionic chromonic molecules using atomistic simulations. The case of TP6EO2M in aqueous solution.

Direct surface-enhanced raman scattering analysis of DNA duplexes (2014)
Journal Article
Guerrini, L., Krpetic, Z., Van Lierop, D., Alvarez-Puebla, R., & Graham, D. (2014). Direct surface-enhanced raman scattering analysis of DNA duplexes. Angewandte Chemie International Edition, 54(4), 1144-1148. https://doi.org/10.1002/anie.201408558

The exploration of the genetic information carried by DNA has become a major scientific challenge. Routine DNA analysis, such as PCR, still suffers from important intrinsic limitations. Surface-enhanced Raman spectroscopy (SERS) has emerged as an out... Read More about Direct surface-enhanced raman scattering analysis of DNA duplexes.

Anticancer phototherapy using activation of E-combretastatins by two-photon–induced isomerization (2014)
Journal Article
Hadfield, J., Bisby, R., Scherer, K., Botchway, S., & Parker, A. (2014). Anticancer phototherapy using activation of E-combretastatins by two-photon–induced isomerization. Journal of Biomedical Optics, 20(5), 1004-1. https://doi.org/10.1117/1.JBO.20.5.051004

The photoisomerization of relatively nontoxic E-combretastatins to clinically active Z-isomers is
shown to occur in solution through both one- and two-photon excitations at 340 and 625 nm, respectively.
The photoisomerization is also demonstrated t... Read More about Anticancer phototherapy using activation of E-combretastatins by two-photon–induced isomerization.

Aspergillus fumigatus proteases, Asp f 5 and Asp f 13, are essential for airway inflammation and remodelling in a murine inhalation model (2014)
Journal Article
Namvar, S., Warn, P., Farnell, E., Bromley, M., Fraczek, M., Bowyer, P., & Herrick, S. (2015). Aspergillus fumigatus proteases, Asp f 5 and Asp f 13, are essential for airway inflammation and remodelling in a murine inhalation model. Clinical and Experimental Allergy, 45(5), 982-993. https://doi.org/10.1111/cea.12426

BACKGROUND: In susceptible individuals, exposure to Aspergillus fumigatus can lead to the development of atopic lung diseases such as allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS). Protease allergen... Read More about Aspergillus fumigatus proteases, Asp f 5 and Asp f 13, are essential for airway inflammation and remodelling in a murine inhalation model.

Network analysis reveals that bacteria and fungi form modules that correlate independently with soil parameters (2014)
Journal Article
soil parameters. Environmental Microbiology, 17(8), 2677-2689. https://doi.org/10.1111/1462-2920.12559

Network and multivariate statistical analyses were
performed to determine interactions between bacterial
and fungal community terminal restriction length
polymorphisms as well as soil properties in paired
woodland and pasture sites. Canonical cor... Read More about Network analysis reveals that bacteria and fungi form modules that correlate independently with soil parameters.

Spectroscopy and fluorescence lifetime imaging in live cells of a cyano-substituted combretastatin (2014)
Journal Article
combretastatin. Biomedical Spectroscopy and Imaging, 3, 211-218. https://doi.org/10.3233/BSI-140067

Fluorescence lifetime imaging has been used to observe the real-time uptake in live mammalian cells of a
combretastatin-type drug analogue that is a substituted stilbene with a cyano group at the bridging olefinic bond. Fluorescence spectra in a ran... Read More about Spectroscopy and fluorescence lifetime imaging in live cells of a cyano-substituted combretastatin.

Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth (2014)
Journal Article
Martinez-Outschoorn, U., Sotgia, F., & Lisanti, M. (2014). Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth. Cancer Cell, 26(1), 5-7. https://doi.org/10.1016/j.ccr.2014.06.021

Profound metabolic differences between cancer cells and fibroblasts promote tumorigenesis. A study by Valencia and colleagues in this issue of Cancer Cell supports this assertion. They observed that metabolic asymmetry in prostate tumors drives aggre... Read More about Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth.

The effects of 2',5'-di(tert-butyl)-1,4-benzohydroquinone (TBQ) on calcium handling in rat ventricular myocytes (2014)
Journal Article
Greensmith, D., Miller, L., & Eisner, D. (2014). The effects of 2',5'-di(tert-butyl)-1,4-benzohydroquinone (TBQ) on calcium handling in rat ventricular myocytes. Proceedings of the Physiological Society (Online), 31, PCA042

2',5'-di(tert-butyl)-1,4-benzohydroquinone (TBQ) is a reversible inhibitor of SERCA, potentially making it a useful tool to study the effects of SERCA inhibition. It has been used in a variety of cell types including ventricular myocytes (1). However... Read More about The effects of 2',5'-di(tert-butyl)-1,4-benzohydroquinone (TBQ) on calcium handling in rat ventricular myocytes.

Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions (2014)
Journal Article
Greensmith, D., Galli, G., Trafford, A., & Eisner, D. (2014). Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions. Cardiovascular Research, 103(4), 554-563. https://doi.org/10.1093/cvr/cvu158

AIMS: Most of the calcium that activates contraction is released from the sarcoplasmic reticulum (SR) through the ryanodine receptor (RyR). It is controversial whether activators of the RyR produce a maintained increase in the amplitude of the systol... Read More about Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions.

MicroRNA profiles discriminate among colon cancer metastasis (2014)
Journal Article

MicroRNAs are being exploited for diagnosis, prognosis and monitoring of cancer and other diseases. Their high tissue specificity and critical role in oncogenesis provide new biomarkers for the diagnosis and classification of cancer as well as predic... Read More about MicroRNA profiles discriminate among colon cancer metastasis.

Understanding digital health as public pedagogy : a critical framework (2014)
Journal Article
Rich, E., & Miah, A. (2014). Understanding digital health as public pedagogy : a critical framework. Societies, 4(2), 296-315. https://doi.org/10.3390/soc4020296

This paper argues on behalf of a public pedagogy approach to developing a critical understanding of digital health technologies. It begins by appraising the hitherto polarised articulations of digital innovation as either techno-utopian or techno-dys... Read More about Understanding digital health as public pedagogy : a critical framework.

Evaluation of genetic association of the INK4 locus with primary open angle glaucoma in East Indian population (2014)
Journal Article
angle glaucoma in East Indian population. Scientific reports, 4, 5115. https://doi.org/10.1038/srep05115

INK4 locus at chromosome 9p21 has been reported to be associated with primary open angle glaucoma (POAG) and its subtypes along with the associated optic disc parameters across the populations of European, Japanese and African ancestries. The locus e... Read More about Evaluation of genetic association of the INK4 locus with primary open angle glaucoma in East Indian population.

Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury (2014)
Journal Article
Gordillo, G., Krpetic, Z., & Brust, M. (2014). Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury. ACS nano, 8(6), 6074-6080. https://doi.org/10.1021/nn501395e

It is demonstrated that a compact monolayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine adsorbed to a hanging mercury drop electrode can serve as a simple electrochemical model system to study biomembrane penetration by gold nanoparticles. The hydrog... Read More about Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury.

Mechanisms of adiponectin-associated perivascular function in vascular disease (2014)
Journal Article
Withers, S., Bussey, C., Saxton, S., Melrose, H., Watkins, A., & Heagerty, A. (2014). Mechanisms of adiponectin-associated perivascular function in vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(8), 1637-42. https://doi.org/10.1161/ATVBAHA.114.303031

The concept that fat cells could influence the circulation and indeed cardiac function has been in existence for ≥20 years and has gained a wide interest and no less excitement as evidence has accrued to suggest that such effects may be profound enou... Read More about Mechanisms of adiponectin-associated perivascular function in vascular disease.