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Guanylate-binding Protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against toxoplasma gondii (2017)
Journal Article

Mesenchymal stromal cells (MSCs) have recently been shown to play important roles in mammalian host defenses against intracellular pathogens, but the molecular mechanism still needs to be clarified. We confirmed that human MSCs (hMSCs) pre-stimulated... Read More about Guanylate-binding Protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against toxoplasma gondii.

Tubulin-binding dibenz[c,e]oxepines: Part 2 Structural variation and biological evaluation as tumour vasculature disrupting agents (2017)
Journal Article
Hadfield, J., Rossington, S., Wallace, T., Shnyder, S., & Williams, K. (2017). Tubulin-binding dibenz[c,e]oxepines: Part 2 Structural variation and biological evaluation as tumour vasculature disrupting agents. Bioorganic and Medicinal Chemistry, 25(5), 1630-1642. https://doi.org/10.1016/j.bmc.2017.01.027

5,7-Dihydro-3,9,10,11-tetramethoxybenz[c,e]oxepin-4-ol 1, prepared from a dibenzyl ether precursor via Pd-catalysed intramolecular direct arylation, possesses broad-spectrum in vitro cytotoxicity towards various tumour cell lines, and induces vascul... Read More about Tubulin-binding dibenz[c,e]oxepines: Part 2 Structural variation and biological evaluation as tumour vasculature disrupting agents.

Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering (2017)
Journal Article

The shape and size of nanoparticles are important parameters affecting the biodistribution, bioactivity, and toxicity. The
high-throughput characterisation of nanoparticle shape in the dispersion is a fundamental prerequisite for realistic in vitro... Read More about Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering.

New Approaches to Photodynamic Therapy from Type I, II and III to Type IV Using One or More Photons (2017)
Journal Article
Scherer, K., Bisby, R., Botchway, S., & Parker, A. (2017). New Approaches to Photodynamic Therapy from Type I, II and III to Type IV Using One or More Photons. Anti-Cancer Agents in Medicinal Chemistry, 17(2), 171-189. https://doi.org/10.2174/1871520616666160513131723

Photodynamic therapy (PDT) is an alternative cancer treatment to conventional surgery, radiotherapy and chemotherapy. It is based on activating a drug with light that triggers the generation of cytotoxic species that promote tumour cell killing. At p... Read More about New Approaches to Photodynamic Therapy from Type I, II and III to Type IV Using One or More Photons.

miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway (2017)
Journal Article
peptides, by targeting CXCR4-p21 pathway. BMC Cancer, 17, 33-43. https://doi.org/10.1186/s12885-016-3003-9

Abstract
Background: Antimicrobial peptides (AMPs) play important roles in the innate immune system of all life forms and
recently have been characterized as multifunctional peptides that have a variety of biological roles such as anticancer
agent... Read More about miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.

Evolutionary diversification of Pseudomonas aeruginosa in an artificial sputum model (2017)
Journal Article
Davies, E., James, C., Brockhurst, M., & Winstanley, C. (2017). Evolutionary diversification of Pseudomonas aeruginosa in an artificial sputum model. BMC Microbiology, 17(3), https://doi.org/10.1186/s12866-016-0916-z

Background
During chronic lung infections of cystic fibrosis patients Pseudomonas aeruginosa populations undergo extensive evolutionary diversification. However, the selective drivers of this evolutionary process are poorly understood. To test the e... Read More about Evolutionary diversification of Pseudomonas aeruginosa in an artificial sputum model.

Switching off malignant mesothelioma : exploiting the hypoxic microenvironment (2017)
Journal Article
Nabavi, N., Bennewith, K., Churg, A., Wang, Y., Collins, C., & Mutti, L. (2017). Switching off malignant mesothelioma : exploiting the hypoxic microenvironment. Genes and Cancer, 7(11-12), 340-354. https://doi.org/10.18632/genesandcancer.124

Malignant mesotheliomas are aggressive, asbestos-related cancers with poor patient prognosis, typically arising in the mesothelial surfaces of tissues in pleural and peritoneal cavity. The relative unspecific symptoms of mesotheliomas, misdiagnoses,... Read More about Switching off malignant mesothelioma : exploiting the hypoxic microenvironment.

Perceptions of play : using Play-Doh to enhance the student experience in bioscience higher education (2017)
Journal Article
Lace-Costigan, G. (2017). Perceptions of play : using Play-Doh to enhance the student experience in bioscience higher education. International Journal of Game-Based Learning, 7(3), 26-37. https://doi.org/10.4018/IJGBL.2017070103

Playful and kinaesthetic learning approaches are used in numerous early years (birth to 5 years old) learning environments, however studies in HE STEM disciplines are uncommon. This study aimed to explore the use of Play-Doh in an undergraduate anato... Read More about Perceptions of play : using Play-Doh to enhance the student experience in bioscience higher education.

Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity (2016)
Journal Article
Bonuccelli, G., Peires-Pages, M., Ozsvari, B., Martinez- Outschoorn, U., Sotgia, F., & Lisanti, M. (2017). Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity. Oncotarget, 8(6), 9868-9884. https://doi.org/10.18632/oncotarget.14196

In this report, we systematically examined the role of telomerase activity in
lung and ovarian cancer stem cell (CSC) propagation. For this purpose, we indirectly
gauged telomerase activity, by linking the hTERT-promoter to eGFP. Using lung
(A549)... Read More about Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity.

Does hydatid cyst fluid from Echinococcus granulosus cysts have any effect on cells involved in fibrosis in cystic echinococcosis? (2016)
Journal Article
Mohammed, A., Allen, J., & Rogan, M. (2016). Does hydatid cyst fluid from Echinococcus granulosus cysts have any effect on cells involved in fibrosis in cystic echinococcosis?. Journal of Parasitology and Bacteriology, 7(5), https://doi.org/10.4172/2155-9597.C1.023

Cystic echinococcosis is characterized by the presence of slow growing hydatid cysts, usually in the liver or lungs. Survival of the parasite is based on an interaction of the host immune system and a range of parasite immune-evasive strategies. Fibr... Read More about Does hydatid cyst fluid from Echinococcus granulosus cysts have any effect on cells involved in fibrosis in cystic echinococcosis?.

Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress (2016)
Journal Article

Somatic variation in DNA can cause cells to deviate from the preordained
genomic path in both disease and healthy conditions. Here, using exome
sequencing of paired tissue samples, we show that the normal human brain
harbors somatic single base va... Read More about Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress.

The differential hormonal milieu of morning versus evening, may have an impact on muscle hypertrophic potential (2016)
Journal Article
Burley, S., Whittingham-Dowd, J., Allen, J., Grosset, J., & Onambele-Pearson, G. (2016). The differential hormonal milieu of morning versus evening, may have an impact on muscle hypertrophic potential. PLoS ONE, 11(9), e0161500. https://doi.org/10.1371/journal.pone.0161500

Substantial gains in muscle strength and hypertrophy are clearly associated with the routine performance of resistance training. What is less evident is the optimal timing of the resistance training stimulus to elicit these significant functional and... Read More about The differential hormonal milieu of morning versus evening, may have an impact on muscle hypertrophic potential.

Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers (2016)
Journal Article
Bennett, A., Sloss, O., Topham, C., Nelson, L., Tighe, A., & Taylor, S. (2016). Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers. Open Biology, 6(8), https://doi.org/10.1098/rsob.160134

Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle assembly checkpoint (SAC) and the intrinsic apoptosis pathway. The mechanistic interplay between these two networks is obscured by functional redundancy a... Read More about Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers.

Oxidative stress and breast cancer biomarkers : the case of the cytochrome P450 2E1 (2016)
Journal Article
Singh, S., Rajendran, R., Kuroda, K., Isogai, E., Krstic-Demonacos, M., & Demonacos, C. (2016). Oxidative stress and breast cancer biomarkers : the case of the cytochrome P450 2E1. Journal of Cancer Metastasis and Treatment, 2, 268-276. https://doi.org/10.20517/2394-4722.2016.42

Aim: The aim of the study is to investigate the impact of the cytochrome P450 2E1, which is the most efficient CYP450 family
member in generating reactive oxygen species (ROS), on cellular energy metabolism of breast cancer cells and therefore the... Read More about Oxidative stress and breast cancer biomarkers : the case of the cytochrome P450 2E1.

Different types of small RNAs in protozoa (2016)
Book Chapter
Zheng, L., Liao, J., Wen, Y., Hide, G., Qu, L., & Lun, Z. (2016). Different types of small RNAs in protozoa. In A. Leitao, & F. Enguita (Eds.), Non-coding RNAs and inter-kingdom communication (177-196). Springer International Publishing. https://doi.org/10.1007/978-3-319-39496-1_11

The origin and evolution of small RNA molecules is a long-standing mystery. The protozoa represent the earliest eukaryotes and encompass rich diverse genetic resources. However, there are many contradictions and disputes prevalent in studies on proto... Read More about Different types of small RNAs in protozoa.

Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols (2016)
Journal Article
Killoran, P., Rossington, S., Wilkinson, J., & Hadfield, J. (2016). Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols. Tetrahedron Letters, 57(35), 3954-3957. https://doi.org/10.1016/j.tetlet.2016.07.076

We report the catalytic chromium-mediated oxidation of secondary allylic alcohols to give α,β-unsaturated aldehydes with exclusive (E)-stereoselectivity. This facile procedure employs catalytic PCC (5 mol%) and periodic acid (H5IO6) as a co-oxidant.... Read More about Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols.

Effect of monoglycerides and fatty acids on a ceramide bilayer (2016)
Journal Article
ceramide bilayer. Physical Chemistry Chemical Physics, 18, 17446 -17460. https://doi.org/10.1039/c6cp01238h

Monoglycerides and unsaturated fatty acids, naturally present in trace amounts in the stratum corneum (top layer of skin) lipid matrix, are commonly used in pharmaceutical, cosmetic and health care formulations. However, a detailed molecular understa... Read More about Effect of monoglycerides and fatty acids on a ceramide bilayer.

Cancer stem cell metabolism (2016)
Journal Article
Peiris-Pagès, M., Martinez-Outschoorn, U., Pestell, R., Sotgia, F., & Lisanti, M. (2016). Cancer stem cell metabolism. Breast Cancer Research, 18(55), https://doi.org/10.1186/s13058-016-0712-6

Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as... Read More about Cancer stem cell metabolism.